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Familial Hypercholesterolemia

Understanding and Diagnosing Familial Hypercholesterolemia: A Comprehensive Guide

High cholesterol is a common health concern affecting millions of people worldwide. However, some individuals may experience an inherited condition called Familial Hypercholesterolemia (FH), which significantly increases the risk of developing heart disease. This blog aims to provide a comprehensive overview of FH, its symptoms, diagnosis, and available treatment options. What is Familial Hypercholesterolemia? Familial […]

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Drug Design

Unlocking the Power of Pharmacophore: The Key Element in Revolutionary Drug Design

Introduction In drug design, pharmacophore is a critical concept that serves as the foundation for discovering and developing new drugs. It refers to the set of chemical and steric features that enables a drug molecule to interact with its target, such as a protein or an enzyme. Decoding pharmacophore is crucial to understanding the underlying

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NGS

Advancements in NGS for Genomic Research: Unveiling the Secrets of our Genomes

Introduction With the rise of genomic research, Next-Generation Sequencing (NGS) has become a crucial tool for scientists and researchers. NGS has revolutionized the way we study genomes by providing faster, more cost-effective, and high-throughput sequencing capabilities. In this blog post, we will explore the advancements in NGS and their impact on genomic research. NGS and

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miRNAs

MicroRNA (miRNA) Function Identification: Studying the roles of miRNAs in gene regulation and disease pathways

Introduction to miRNAs: MicroRNAs (miRNAs) are a fascinating class of small, single-stranded, non-coding RNAs consisting of 19–25 nucleotides. These tiny molecules play a significant role in modulating gene expression post-transcriptionally, thereby influencing various cellular processes. Definition of miRNAs: MiRNAs are crucial players in the intricate network of gene regulation within cells. Despite their small size,

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molecular modeling

Unveiling the Power of Molecular Modeling in Drug Design

1. Introduction to Molecular Modeling in Drug Design   Molecular modeling is a powerful tool that has revolutionized the field of drug design. By utilizing computational techniques to study the behavior of molecules at the atomic level, scientists can predict the interactions between drugs and their biological targets with unprecedented accuracy. In this blog post,

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protein

Enhancing Protein Structure Prediction through Deep Learning

Introduction: Proteins are vital for life, performing various functions crucial for organisms. Understanding their 3D structures is essential, yet experimental determination is challenging and resource-intensive. Computational methods offer a solution, with Template-based Modeling (TBM) and Free Modeling (FM) being the main approaches. Template-Based Modeling (TBM): TBM relies on existing structures as templates, assuming sequence similarity

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Genomics

Future Trends and Emerging Technologies in Genomics

Genomics, the study of an organism’s complete set of DNA, continues to advance at a rapid pace, driving transformative innovations in biomedical research, healthcare, agriculture, and beyond. As technology evolves, new trends and emerging technologies are shaping the landscape of genomics, offering unprecedented opportunities for understanding genetic variation, disease mechanisms, and personalised medicine. This article

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Genetic Inheritance

Next-Generation Sequencing and Bioinformatics Analysis of Family Genetic Inheritance

Introduction Mendelian and complex genetic diseases pose significant challenges to both affected individuals and society. While Mendelian diseases result from mutations in a single gene, complex trait diseases arise from the accumulation of mutations in linked or unlinked genomic regions. Unfortunately, many of these conditions remain undiagnosed due to the limitations of conventional diagnostic tests.

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How to use computational methods to overcome current and future obstacles in developing new therapies

Introduction The development of new therapies for diseases is a challenging and costly process that requires extensive research, testing, and approval. Many potential drugs fail to reach the market due to lack of efficacy, safety, or profitability. Therefore, there is a need for innovative and efficient methods to accelerate and improve the drug discovery and

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Machine Learning

The Synergy of Machine Learning and Next-Generation Sequencing

Machine learning (ML) and next-generation sequencing (NGS) have significantly transformed genomics, offering valuable tools for understanding the structure, function, and evolution of genomes, as well as advancing disease diagnosis and treatment. ML, a subset of artificial intelligence, facilitates computers in learning from data and making predictions without explicit programming, while NGS is a high-throughput technique

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